CTK知识史家岚，黑龙江省血液肿瘤研究所出凝血研究室主任，黑龙江省龙江学者，医学参考报血液病频道学术发展部主任，哈尔滨医科大学血液内科教授，博士生导师。国家自然科学基金课题评审专家；Blood, J Thrombosis and Haemostasis, Thrombosis and Haemostasis指定审稿人。
人物经历
1、 ?198301-198601：哈尔滨医科大学 ?基础医学系，助教
2、 ?198901-199101：哈尔滨医科大学 ?附属第一医院研究部，主管
3、 ?199101-199301：东京医科齿科大学 ?医学部，研究员
4、 ?199701-199801：东京医科齿科大学 ?医学部，讲师
5、 ?199801-200701：哈佛医学院 ?布里根医院血液肿瘤科，研究员，讲师
6、 ?200701-：·哈尔滨医科大学 ?附属第一医院血液内科，教授，博士生导师
著述成果
成果论文
1、 ?Apoptosis of Neutrophils and Their Elimination by Kupffer Cell in Rat Liver.,Hepatology,1996; 24(5),第一作者
2、 ?Expression of P-selectin on hepatic endothelia and platelets promoting neutrophil removal by liver macrophages.,Blood,1998; 92(2),第一作者
3、 ?Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride.,Am J Pathol,1998; 153(2),第一作者
4、 ?Role of the liver in regulating numbers of circulating neutrophils.,Blood,2001; 98(4),第一作者
5、 ?Lactadherin inhibits enzyme complexes of blood coagulation by completing for phospholipid binding sites.,Blood,2003; 101(7),第一作者
6、 ?Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature.,Biochim Biophys Acta,2004; 1667(1),第一作者
7、 ?Lactadherin detects early phosphatidylserine exposure on immortalized leukemia cells undergoing programmed cell death.,Cytometry A,2006; 69(12),第一作者
8、 ?Platelet phosphatidylserine exposure during thrombosis is predominantly partial rather than complete:in vitro and in vivo detection utilizing lactadherin.,J Thromb Haemost,2008; 6(7),第一作者
9、 ?Procoagulant activity and phosphatidylserine of amniotic fluid cells.,Thromb Haemost,2009; 101(5),通讯作者
10、 ? Daunorubicin induces procoagulant activity of cultured endothelial cells through phosphatidylserine.,Thromb Haemost,2010;104(6),通讯作者
11、 ?Lactadherin functions as a probe for phosphatidylserine exposure and as an anticoagulant in the study of stored platelets.,Vox Sang,2011; 100(2),通讯作者
12、 ?Phagocytosis by macrophages and endothelial cells inhibits procoagulant and fibrinolytic activity of acute promyelocytic leukemia cells.,Blood,2012;119(10),通讯作者
13、 ?Homocysteine enhances clot-promoting activity of endothelial cells via phosphatidylserine externalization and microparticles formation.,Amino Acids,2012;43(3),通讯作者
14、 ? Effect of arsenic trioxide and daunorubicin on procoagulant activity of acute promyelocytic leukemia cells., Zhonghua Yi Xue Za Zhi,2012;92(16),通讯作者
15、 ?Procoagulant activity of erythrocytes and platelets through phosphatidylserine exposure and microparticles release in patients with nephrotic syndrome.,Thromb Haemost,2012；107(4),通讯作者
16、 ?Endothelial cell phagocytosis of senescent neutrophils decreases procoagulant activity.,Thromb Haemost,2013;109(6),通讯作者
17、 ?Role of erythrocytes and platelets in the prothrombotic status in polycythemia vera through phosphatidylserine exposure and microparticle generation.,Thromb Haemost,2013;109(6),并列一作
18、 ?Extracellular DNA traps released by acute promyelocytic leukemia cells through autophagy. ,Cell Death and Disease,2016;7(6),通讯作者
19、 ?Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease.,Thromb Haemost,2016;115(4),通讯作者
20、 ?Promyelocytic extracellular chromatin exacerbates coagulation and fibrinolysis in acute promyelocytic leukemia.,Blood,2017;129(13),通讯作者
21、 ?Microparticles and blood cells induce procoagulant activity via phosphatidylserine exposure in NSTEMI patients following stent implantation.,International Journal of Cardiology,2016;223,通讯作者
22、 ?Enhanced Procoagulant Activity on Blood Cells after Acute Ischemic Stroke.,Translational stroke research,2017;8(1),通讯作者
23、 ?Phosphatidylserine on blood cells and endothelial cells contributes to the hypercoagulable state in cirrhosis.,Liver Int ,2016;36(12),通讯作者
24、 ?Circulating microparticles, blood cells and endothelium induce procoagulant activity in sepsis through phosphatidylserine exposure.,Shock,2016;45(3),通讯作者
25、 ?Procoagulant activity induced by transcatheter closure of atrial septal defects is associated with exposure of phosphatidylserine on microparticles, platelets and red blood cells.,Thrombosis research,2015;136(2),通讯作者
科研方向
主要研究方向: 白细胞及血小板生物学及其体内平衡 细胞成熟和凋亡过程细胞膜磷脂分析 乳粘素的功能和作用机制 APL凝血异常的分子病理 心血管疾病血栓形成机制。
荣誉记录
1、 ?体外LAK细胞杀伤人肺癌细胞的研究,黑龙江省科学技术进步奖,三等奖,199101。
